The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis
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چکیده
منابع مشابه
Title: The Role of Guanylyl Cyclase C During Intestinal Adaptation
Introduction: Following a proximal small bowel resection (SBR), the intestine adapts by increased crypt depth and villus height compared to sham operated mice (transection and reanastomosis only). The epidermal growth factor receptor (EGFR) is a known mediator of intestinal adaptation and results in activation of the GTPase Rac. This activates PAK (p21-activated protein kinase) which may activa...
متن کاملThe regulation and physiological roles of the guanylyl cyclase receptors.
CYCLIC guanosine 3', 5'-monophosphate (cGMP) was the second of the cyclic nucleotide "second messengers" discovered [1-3] and 35 years later, its role in many cells remains unclear. It has been suggested that the rate of cGMP turnover is one means by which this nucleotide signals [4], but most studies suggest cells monitor intracellular cGMP concentrations, which are regulated by guanylyl cycla...
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Guanylyl cyclase C, a receptor for bacterial diarrheagenic enterotoxins, is expressed selectively by intestinal epithelium and is an endogenous downstream target of CDX2. The expression of Guanylyl cyclase C is preserved throughout the adenoma/carcinoma sequence in the colorectum. Detection of Guanylyl cyclase C expression by reverse transcriptase-polymerase chain reaction is currently being va...
متن کاملGlycosylation of human receptor guanylyl cyclase C
Background Post translational modifications regulate several signalling pathways and glycosylation is emerging as a key player in this regulatory process. Glycosylation of cell surface receptors modulate the downstream signalling pathway and when altered causes a change in the normal physiology of the cell [1]. Guanylyl cyclase C (GC-C) belongs to a group of membrane bound receptors that produc...
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Nitric oxide (NO) stimulates cGMP synthesis by activating its intracellular receptor, soluble guanylyl cyclase (sGC). It is a currently prevailing concept that No and cGMP inhibits platelet function. However, the data supporting the inhibitory role of NO/sGC/cGMP in platelets have been obtained either in vitro or using whole body gene deletion that affects vessel wall function. Here we have gen...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2012
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2012.07.028